The Samikhsya Bureau
NEW DELHI: Scientists have developed a small molecule that disrupts the mechanism through which neurons become dysfunctional in Alzheimer’s disease.
The molecule could be a potential drug candidate to halt or cure the leading cause of dementia worldwide.
A team of scientists led by Professor T. Govindaraju from Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), an autonomous institute of the Department of Science & Technology, Government of India, designed and synthesized a set of novel small molecules and identified a lead candidate which they found could reduce the toxicity of Amyloid Beta toxicity.
The detailed studies established the molecule called TGR63 as the lead candidate to rescue neuronal cells from amyloid toxicity.
Remarkably, the molecule was also found to reduced amyloid burden in the cortex and hippocampus, or a complex part embedded deep into the temporal lobe, thereby reversing cognitive decline.
Currently available treatments provide only temporary relief, and there are no approved drugs that directly act on the disease mechanisms of Alzheimer’s disease. Thus, there is an unmet need to develop drug candidates to halt or cure Alzheimer’s disease.
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